Artículos de revistas
Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism
Fecha
2015-12Registro en:
Wolfson, Manuel Luis; Schander, Julieta Aylen; Bariani, Maria Victoria; Correa, Fernando Gabriel; Franchi, Ana Maria; Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism; Elsevier Science; European Journal of Pharmacology; 769; 12-2015; 110-116
0014-2999
Autor
Wolfson, Manuel Luis
Schander, Julieta Aylen
Bariani, Maria Victoria
Correa, Fernando Gabriel
Franchi, Ana Maria
Resumen
Genital tract infections caused by Gram-negative bacteria induce miscarriage and are one of the most common complications of human pregnancy. LPS administration to 7-day pregnant mice induces embryo resorption after 24h, with nitric oxide playing a fundamental role in this process. We have previously shown that progesterone exerts protective effects on the embryo by modulating the inflammatory reaction triggered by LPS. Here we sought to investigate whether the in vivo administration of progesterone modulated the LPS-induced nitric oxide production from peripheral blood mononuclear cells from pregnant and non-pregnant mice. We found that progesterone downregulated LPS-induced nitric oxide production by a progesterone receptor-independent mechanism. Moreover, our results suggest a possible participation of glucocorticoid receptors in at least some of the anti-inflammatory effects of progesterone.