Artículos de revistas
Evaluation of constitutional chromosome aberrations in hematologic disorders
Fecha
2002-04Registro en:
Cerretini, Roxana; Acevedo, Susana Haydee; Chena, Christian; Belli, Carolina Bárbara; Larripa, Irene Beatriz; et al.; Evaluation of constitutional chromosome aberrations in hematologic disorders; Elsevier Science Inc; Cancer Genetics And Cytogenetics; 134; 2; 4-2002; 133-137
0165-4608
CONICET Digital
CONICET
Autor
Cerretini, Roxana
Acevedo, Susana Haydee
Chena, Christian
Belli, Carolina Bárbara
Larripa, Irene Beatriz
Slavutsky, Irma Rosa
Resumen
We have reviewed 4164 patients with various hematologic disorders cytogenetically studied in our laboratory during the last 25 years to analyze the frequency of constitutional chromosome aberrations (CCA) and to evaluate their association with hematologic malignancies. Our population of patients included 1133 pediatric patients and 3031 adults. Twenty-four (0.58%) cases showed CCA. They included four patients with Robertsonian translocations, one patient with a balanced translocation, two patients with sex chromosome abnormalities, and 17 cases with Down syndrome (DS). Nonsignificant differences among the frequency of patients with CCA from our hematologic series and those observed in the two largest combined surveys of livebirth published (0.65-0.84%) were found. The incidence of DS patients in our population (0.41%) was approximately three times higher than of that observed at birth (0.12-0.17%; P<0.001). The total incidence of constitutional chromosome abnormalities in the non-DS hematologic patients was 0.168% (7 of 4164) lower than of that observed in the newborn population (0.51-0.67%; P<0.001). Nonsignificant differences were found when the incidences of structural aberrations and sex chromosome anomalies were individually compared with the data of the overall population. Our results suggest that the presence of a CCA, other than DS, would not predispose patients to hematologic malignancies. © 2002 Elsevier Science Inc. All rights reserved.