dc.creator | García, Mariana Gabriela | |
dc.creator | Alaniz, Laura Daniela | |
dc.creator | Cordo Russo, Rosalia Ines | |
dc.creator | Alvarez, Elida Ester | |
dc.creator | Hajos, Silvia Elvira | |
dc.date.accessioned | 2017-09-18T16:01:07Z | |
dc.date.accessioned | 2018-11-06T16:07:53Z | |
dc.date.available | 2017-09-18T16:01:07Z | |
dc.date.available | 2018-11-06T16:07:53Z | |
dc.date.created | 2017-09-18T16:01:07Z | |
dc.date.issued | 2008-07 | |
dc.identifier | García, Mariana Gabriela; Alaniz, Laura Daniela; Cordo Russo, Rosalia Ines; Alvarez, Elida Ester; Hajos, Silvia Elvira; PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines; Elsevier; Leukemia Research; 33; 2; 7-2008; 288-296 | |
dc.identifier | 0145-2126 | |
dc.identifier | http://hdl.handle.net/11336/24464 | |
dc.identifier | 1873-5835 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1904880 | |
dc.description.abstract | Upregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been described in some tumors related to multidrug resistance (MDR). The aim of this work was to analyze the relationship between PI3K/Akt, MDR and NF-kappaB in murine lymphoma cell lines resistant to vincristine (LBR-V160) and doxorubicin (LBR-D160) as well as in the sensitive line (LBR-). PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines. Vincristine but not doxorubicin increased p-Akt expression whereas co-treatment with PI3K inhibitors and vincristine increased apoptosis in the three cell lines. Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity. We concluded that the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.lrjournal.com/article/S0145-2126(08)00288-9/fulltext | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.leukres.2008.06.010 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0145212608002889 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | MDR | |
dc.subject | LYMPHOMA | |
dc.subject | PI3K | |
dc.subject | PgP | |
dc.subject | DRUG RESISTANCE | |
dc.title | PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |