Artículos de revistas
Lipophilicity of Novel 5-Carbonates of Lamivudine With Antirretroviral Activity. Correlation Between Different Methods
Fecha
2008-07Registro en:
Ravetti, Soledad; Gualdesi, María Soledad; Briñon, Margarita Cristina; Lipophilicity of Novel 5-Carbonates of Lamivudine With Antirretroviral Activity. Correlation Between Different Methods; Taylor; Journal of Liquid Chromatography and Related Technologies; 31; 7; 7-2008; 1014-1032
1082-6076
1520-572X
CONICET Digital
CONICET
Autor
Ravetti, Soledad
Gualdesi, María Soledad
Briñon, Margarita Cristina
Resumen
This study reports on the lipophilicity of novel 5′‐carbonates of lamivudine with anti‐HIV activity. Reversed‐phase thin layer chromatography (RP‐TLC), reversed‐phase high performance liquid chromatography (RP‐HPLC), conventional shake flask (log Poct), and the theoretical CLOGP methods were used, in order to establish if the linear relationships between the conventional and chromatographic methods permit an extrapolation procedure. The nature of the organic modifiers used in the chromatographic techniques did not substantially affect the measurement of lipophilicity, since a good correlation between experimental log Poct and extrapolated RP‐TLC and RP‐HPLC values (RMw and log k′w, respectively) supported the validity of the extrapolation technique.