Artículos de revistas
Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
Fecha
2013-02Registro en:
Ramos, R. A.; Zapata, Jair; Condat, Carlos; Deisboeck, Thomas S.; Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 392; 10; 2-2013; 2415-2425
0378-4371
CONICET Digital
CONICET
Autor
Ramos, R. A.
Zapata, Jair
Condat, Carlos
Deisboeck, Thomas S.
Resumen
A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.