Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

Giri, German Francisco; Danielli, Mauro; Marinelli, Raul Alberto; Spanevello, Rolando Angel

Artículos de revistas

Fecha

2016-08

Registro en:

Giri, German Francisco; Danielli, Mauro; Marinelli, Raul Alberto; Spanevello, Rolando Angel; Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 26; 16; 8-2016; 3955-3957

0960-894X

http://hdl.handle.net/11336/52667

CONICET Digital

CONICET

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1903728

Autor

Giri, German Francisco

Danielli, Mauro

Marinelli, Raul Alberto

Spanevello, Rolando Angel

Institución

Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)

Resumen

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50values of cisplatin, a frequently administered chemotherapy drug.

Materias

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