info:eu-repo/semantics/article
Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
Fecha
2014-02Registro en:
Capdevila, Daiana Andrea; Álvarez Paggi, Damián Jorge; Castro, Maria Ana; Tórtora, Verónica; Demicheli, Verónica; et al.; Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c; Royal Society of Chemistry; Chemical Communications; 50; 20; 2-2014; 2592-2594
1359-7345
CONICET Digital
CONICET
Autor
Capdevila, Daiana Andrea
Álvarez Paggi, Damián Jorge
Castro, Maria Ana
Tórtora, Verónica
Demicheli, Verónica
Estrin, Dario Ariel
Radi, Rafael
Murgida, Daniel Horacio
Resumen
Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.