Artículos de revistas
Preyssler catalyst-promoted rapid, clean, and efficient condensation reactions for 3H-1,5-benzodiazepine synthesis in solvent-free conditions
Fecha
2013-09-28Registro en:
Pasquale, Gustavo Antonio; Ruiz, Diego Manuel; Jios, Jorge Luis; Autino, Juan Carlos; Romanelli, Gustavo Pablo; Preyssler catalyst-promoted rapid, clean, and efficient condensation reactions for 3H-1,5-benzodiazepine synthesis in solvent-free conditions; Elsevier; Tetrahedron Letters; 54; 48; 28-9-2013; 6574-6579
0040-4039
CONICET Digital
CONICET
Autor
Pasquale, Gustavo Antonio
Ruiz, Diego Manuel
Jios, Jorge Luis
Autino, Juan Carlos
Romanelli, Gustavo Pablo
Resumen
A simple, convenient, and environmentally benign synthesis of 1,5-benzodiazepines is developed by condensing different o-phenylenediamines and 1,3-aryl-1,3-propanodiones. The reaction is catalyzed by a Preyssler (NaH14P5W30O110, HPA) heteropolyacid as a safe, clean, and recyclable catalyst. The method is operationally simple and provides access to a variety of 1,5-benzodiazepines in good to excellent yields.