Artículos de revistas
Arene cis-Diol Dehydrogenase-Catalysed Regio- and Stereoselective Oxidation of Arene-, Cycloalkane- and Cycloalkene-cis-diols to Yield Catechols and Chiral α-Ketols
Fecha
2015-05Registro en:
Boyd, Derek R.; Sharma, Narain D.; Berberian, Victoria; Cleij, Marcel; Hardacre, Christopher; et al.; Arene cis-Diol Dehydrogenase-Catalysed Regio- and Stereoselective Oxidation of Arene-, Cycloalkane- and Cycloalkene-cis-diols to Yield Catechols and Chiral α-Ketols; Wiley VCH Verlag; Advanced Synthesis & Catalysis (print); 357; 8; 5-2015; 1881-1894
1615-4150
CONICET Digital
CONICET
Autor
Boyd, Derek R.
Sharma, Narain D.
Berberian, Victoria
Cleij, Marcel
Hardacre, Christopher
Ljubez, Vera
McConville, Gareth
Stevenson, Paul J.
Kulakov, Leonid A.
Allen, Christopher C. R.
Resumen
Benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase enzymes, expressed in Pseudomonas putida wild-type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis-diols. The dehydrogenase-catalysed production of enantiopure cis-diols, α-ketols and catechols, using benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated.