Artículos de revistas
N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
Fecha
2013-07Registro en:
Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Agnese, Mariel; N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus; Elsevier; Tetrahedron Letters; 54; 38; 7-2013; 5197-5200
0040-4039
Autor
Vallejo, Mariana Guadalupe
Ortega, María Gabriela
Cabrera, Jose Luis
Agnese, Mariel
Resumen
The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.