Artículos de revistas
Rho GTPases as therapeutic targets in cancer (Review)
Fecha
2017-10Registro en:
Cardama, Georgina Alexandra; González, Nazareno; Maggio, J.; Lorenzano Menna, Pablo; Gomez, Daniel Eduardo; Rho GTPases as therapeutic targets in cancer (Review); Spandidos Publications; International Journal of Oncology; 51; 4; 10-2017; 1025-1034
1019-6439
1791-2423
CONICET Digital
CONICET
Autor
Cardama, Georgina Alexandra
González, Nazareno
Maggio, J.
Lorenzano Menna, Pablo
Gomez, Daniel Eduardo
Resumen
Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.