Artículos de revistas
Formulation and characterization of polysaccharide microparticles for pulmonary delivery of sodium cromoglycate
Fecha
2017-07Registro en:
Gallo, Loreana Carolina; Bucala, Veronica; Ramírez Rigo, María Veronica; Formulation and characterization of polysaccharide microparticles for pulmonary delivery of sodium cromoglycate; Springer; AAPS Pharmscitech; 18; 5; 7-2017; 1634-1645
1530-9932
CONICET Digital
CONICET
Autor
Gallo, Loreana Carolina
Bucala, Veronica
Ramírez Rigo, María Veronica
Resumen
Sodium cromoglycate (SC) is an antiasthmatic and antiallergenic drug commonly used for chronic inhalation therapy, however many daily intakes are required due to the fast drug clearance from airways. For these reasons, SC polymeric particles for inhalatory administration with adequate aerosolization and mucoadhesive properties were designed to prolong the drug residence time in the site of action. Sodium carboxymethylcellulose (CMCNa), sodium hyaluronate and sodium alginate were selected to co-process SC by spray drying. The influence of these polysaccharides on the spray drying process and powder quality were evaluated (among others, morphology, size, moisture content, hygroscopicity, flowability, densities, liquid sorption and stability). In vitro aerosolization, drug release and mucoadhesion performance were also studied. Particularly, a novel method to comparatively evaluate the interaction between formulations and mucin solution (mucoadhesion test) was proposed as a rapid methodology to measure adhesion properties of inhalable particles, being the results as indicative of clearance probability. Among all the studied formulations, the powder based on SC and CMCNa exhibited the best mucoadhesion and aerosolization performance, the highest process yield and adequate moisture content, hygroscopicity and stability. SC-CMCNa formulation arose as a promising inhalatory system to reduce the daily intakes and to increase the patient compliance.