info:eu-repo/semantics/article
In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins
Fecha
2013-12Registro en:
Cornier, Patricia Griselda; Delpiccolo, Carina Maria Lujan; Mascali, Florencia Carla; Boggian, Dora Bernarda; Mata, Ernesto Gabino; et al.; In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins; Royal Society of Chemistry; Medicinal Chemistry Communication; 5; 2; 12-2013; 214-218
2040-2503
Autor
Cornier, Patricia Griselda
Delpiccolo, Carina Maria Lujan
Mascali, Florencia Carla
Boggian, Dora Bernarda
Mata, Ernesto Gabino
Cárdenas, Mariano Gonzalo
Blank, Viviana Claudia
Roguin, Leonor Patricia
Resumen
A library of triazolyl aminoacyl(peptidyl) penicillins was designed, synthesized, and evaluated for their antiproliferative activity against HeLa and B16-F0 cell lines. Structure–activity relationship studies were carried out, and minimal structural requirements were determined. Among the tested compounds, derivatives 7f, 7p and 7m demonstrated the highest anticancer activity and a promising selectivity profile against these two cell lines.