Artículos de revistas
Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
Fecha
2010-02Registro en:
Reynoso, Rita Paola; Laufer, Natalia Lorna; Bolcic, Federico Martin; Quarleri, Jorge Fabian; Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients; Elsevier Science; Virus Research; 147; 2; 2-2010; 284-287
0168-1702
Autor
Reynoso, Rita Paola
Laufer, Natalia Lorna
Bolcic, Federico Martin
Quarleri, Jorge Fabian
Resumen
Replicative senescence of peripheral blood mononuclear cells (PBMC) plays an important role in the pathophysiology of chronic viral infections. Although there are controversial reports concerning telomerase activity in HIV monoinfected subjects, no data on HIV–HCV coinfected individuals is available. In this cross-sectional study telomerase activity was quantified in non-stimulated and mitogen-stimulated PBMC lysates from HIV-1 monoinfected and HIV–HCV coinfected individuals using real-time PCR. Up-regulation of telomerase activity after mitogen stimulation was impaired in PBMC of HIV monoinfected and HIV–HCV coinfected patients. The lack of an appropriate induction of this enzymatic activity after stimulus could partly account for immunosuppressive conditions observed in such patients.