info:eu-repo/semantics/article
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles
Fecha
2017-03Registro en:
Porta, Exequiel Oscar Jesús; Jäger, Sebastián N.; Nocito, Isabel; Lepesheva, Galina I.; Serra, Esteban Carlos; et al.; Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles; Royal Society of Chemistry; MedChemComm; 8; 5; 3-2017; 1015-1021
2040-2503
2040-2511
CONICET Digital
CONICET
Autor
Porta, Exequiel Oscar Jesús
Jäger, Sebastián N.
Nocito, Isabel
Lepesheva, Galina I.
Serra, Esteban Carlos
Tekwani, Babu L.
Labadie, Guillermo Roberto
Resumen
A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and then fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.