info:eu-repo/semantics/article
Distribution of telomeric sequences (TTAGGG)n in rearranged chromosomes of Phyllotine Rodents (Cricetidae, Sigmodontinae)
Fecha
2016-04Registro en:
Lanzone, Cecilia; Labaroni, Carolina Alicia; Suárez, Natalia; Rodriguez, Maria Daniela; Herrera, Macarena Lorena; et al.; Distribution of telomeric sequences (TTAGGG)n in rearranged chromosomes of Phyllotine Rodents (Cricetidae, Sigmodontinae); Karger; Cytogenetic And Genome Research; 147; 4; 4-2016; 247-252
1424-8581
1424-859X
CONICET Digital
CONICET
Autor
Lanzone, Cecilia
Labaroni, Carolina Alicia
Suárez, Natalia
Rodriguez, Maria Daniela
Herrera, Macarena Lorena
Bolzan, Alejandro Daniel
Resumen
Phyllotines are sigmodontine rodents endemic to South America with broad genetic variability, Robertsonian polymorphisms being the most frequent. Moreover, this taxon includes a species with multiple sex chromosomes, which is infrequent in mammals. However, molecular cytogenetic techniques have never been applied to phyllotines to elucidate their karyotypic evolution. We studied the chromosomes of 4 phyllotine species using FISH with a pantelomeric probe (TTAGGG)n. Graomys griseoflavus, Eligmodontia puerulus, and E. morgani are polymorphic for Robertsonian translocations, whereas Salinomys delicatus possesses XX/ XY1Y2 sex chromosomes. Telomeric signals were detected at both ends of all chromosomes of the studied species. In S. delicatus interstitial telomeric sequences (ITS) were observed in the 3 major chromosome pairs, which are equidistant from one of the telomeres in these chromosomes. These results suggest that ITS are important in the reshuffling of the highly derived karyotype of S. delicatus. Considering the phylogeny of phyllotines, the Robertsonian rearrangements of G. griseoflavus, E. puerulus, and E. morgani possibly represent chromosome fusions which have occurred independently. The pericentromeric regions of the biarmed chromosomes of these species do not contain telomeric sequences characteristic for strict fusions of recent origin, suggesting a common pattern of telomeric repeat loss during chromosomal evolution of these rodents.