Artículos de revistas
Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
Fecha
2013-12Registro en:
Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-68
0969-8043
CONICET Digital
CONICET
Autor
Garabalino, Marcela Alejandra
Heber, Elisa Mercedes
Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Molinari, Ana Julia
Nigg, David W.
Bauer, William
Trivillin, Verónica Andrea
Schwint, Amanda Elena
Resumen
Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.