Artículos de revistas
Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy
Fecha
2013-08Registro en:
Calles, Javier Adrián; Tartara, Luis Ignacio; Lopez Garcia, Alberto Raul; Diebold Luque, Yolanda; Palma, Santiago Daniel; et al.; Novel bioadhesive hyaluronan-itaconic acid crosslinked films for ocular therapy; Elsevier Science; International Journal Of Pharmaceutics; 455; 1-2; 8-2013; 48-56
0378-5173
CONICET Digital
CONICET
Autor
Calles, Javier Adrián
Tartara, Luis Ignacio
Lopez Garcia, Alberto Raul
Diebold Luque, Yolanda
Palma, Santiago Daniel
Valles, Enrique Marcelo
Resumen
New hyaluronic acid (HA)–itaconic acid (IT) films have been previously synthesized and used as potential topical drug delivery systems (DDS) for ocular administration. In this study we explored homogeneous and heterogeneous crosslinking reactions of HA using glutaraldehyde (GTA) and polyethylene glycol diglycidyl ether (PEGDE) in the presence of IT, a naturally occurring compound that is non-toxic and readily biodegradable. We have studied the morphology, mechanical properties and in vitro biocompatibility between these new materials and ocular surface cells (human corneal epithelial cell line) and evaluated the biopharmaceutical performance of the designed formulations. Although all the synthesized materials exhibited good mechanical properties, the PEGDE modified films exhibited the best biocompatibility, with in vivo assays showing good adhesive performance and minimal irritation. PEGDE films were also tested for their effects in the treatment of intraocular pressure (IOP) in rabbits using timolol maleate (TM) as the model drug. These results may be useful for further design of novel bioadhesive matrix containing drugs by topical application in ophthalmology.