Chromosomal instability in chronic myeloid leukemia: Philadelphia breakpoints are independent of spontaneous breakage and fragile sites

Abstract

Increased frequencies of spontaneous and bromodeoxyuridine induced breakages with a non-random distribution of breakpoints were found in patients with chronic myeloid scientific correspondence 1105 Haematologica vol. 85(10):October 2000 leukemia, suggesting the presence of chromosome instability. Bands 9q34 or 22q11 were not damaged in these patients, demonstrating that the origin of the Philadelphia chromosome is independent of spontaneous breakage or fragile site expression.