Artículos de revistas
The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
Fecha
2013-02Registro en:
Martinez, Fernando Fabian; Cervi, Laura Alejandra; Knubel, Carolina Paola; Panzetta-Dutari, Graciela Maria del Valle; Motran, Claudia Cristina; The role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response; Wiley; American Journal of Reproductive Immunology; 69; 4; 2-2013; 383-394
1046-7408
CONICET Digital
CONICET
Autor
Martinez, Fernando Fabian
Cervi, Laura Alejandra
Knubel, Carolina Paola
Panzetta-Dutari, Graciela Maria del Valle
Motran, Claudia Cristina
Resumen
Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancyspecific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.