Artículos de revistas
Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
Fecha
2013-10Registro en:
Vulcano, Marisa; Sales, Maria Elena; Lombardi, Maria Gabriela; Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?; Hindawi Publishing Corporation; International Scholarly Research Notices; 2013; 486545; 10-2013; 1-12
2356-7872
Autor
Vulcano, Marisa
Sales, Maria Elena
Lombardi, Maria Gabriela
Resumen
Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade it (choline acetyltransferase and acetylcholinesterase) as well as muscarinic (mAChRs) and nicotinic receptors conform the non-neuronal cholinergic system (nNCS). It has been reported that nNCS regulates basal cellular functions including survival, proliferation, adhesion, and migration. Moreover, nNCS is broadly expressed in tumors and in different components of the immune system. In this review, we summarize the role of nNCS in tumors and in different immune cell types focusing on the expression and function of mAChRs in breast tumors and dendritic cells (DCs) and discussing the role of DCs in breast cancer.