Artículos de revistas
Telomerase regulation: a key to inhibition? (Review)
Fecha
2013-09Registro en:
Mengual Gómez, Diego Luis; Farina, Hernán Gabriel; Gomez, Daniel Eduardo; Telomerase regulation: a key to inhibition? (Review); Spandidos Publ Ltd; International Journal Of Oncology; 43; 5; 9-2013; 1351-1356
1019-6439
1791-2423
CONICET Digital
CONICET
Autor
Mengual Gómez, Diego Luis
Farina, Hernán Gabriel
Gomez, Daniel Eduardo
Resumen
Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different levels of regulation, including control of expression, phosphorylation state, assembly and transportation to sites of activity. Thus, we emphasize that targeting telomerase expression or activity is not the only way to shorten telomeres, induce cell senescence and apoptosis. Therefore, there are multiple sites capable of allowing the modulation of its enzymatic activity. In the development of strategies based on the regulation of telomerase activity the understanding of the mechanisms regulating their subunits is essential. Based on this, in this review we summarize the current state of knowledge of some regulatory mechanisms of the components of the telomerase complex, and hypothetize their potential therapeutic application against cancer.