Asociación entre polimorfismos del gen NAT2 y fisura labioleporina no sindrómica en Argentina
Association between NAT2 polymorphisms with non-syndromic cleft lip with or without cleft palate in Argentina
dc.creator | Santos, María Rita | |
dc.creator | Ramallo, Virginia | |
dc.creator | Muzzio, Marina | |
dc.creator | López Camelo, Jorge Santiago | |
dc.creator | Bailliet, Graciela | |
dc.date.accessioned | 2017-11-02T14:54:11Z | |
dc.date.accessioned | 2018-11-06T14:44:46Z | |
dc.date.available | 2017-11-02T14:54:11Z | |
dc.date.available | 2018-11-06T14:44:46Z | |
dc.date.created | 2017-11-02T14:54:11Z | |
dc.date.issued | 2015-04 | |
dc.identifier | Santos, María Rita; Ramallo, Virginia; Muzzio, Marina; López Camelo, Jorge Santiago; Bailliet, Graciela; Asociación entre polimorfismos del gen NAT2 y fisura labioleporina no sindrómica en Argentina; Soc Medica Santiago; Revista Médica De Chile; 143; 4; 4-2015; 444-450 | |
dc.identifier | 0034-9887 | |
dc.identifier | http://hdl.handle.net/11336/27380 | |
dc.identifier | 0717-6163 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1889789 | |
dc.description.abstract | Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment. Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP. Material and methods: We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT). Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio=1.6; p=0.03). Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP. | |
dc.language | spa | |
dc.publisher | Soc Medica Santiago | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3406 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | ARYLAMINE | |
dc.subject | N-ACETILTRANSFERASE | |
dc.subject | CLEFT LIP | |
dc.subject | CLEFT PALATE | |
dc.title | Asociación entre polimorfismos del gen NAT2 y fisura labioleporina no sindrómica en Argentina | |
dc.title | Association between NAT2 polymorphisms with non-syndromic cleft lip with or without cleft palate in Argentina | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas |