Artículos de revistas
Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa
Fecha
2010-05-01Registro en:
Veaute, Carolina Melania Isabel; Liu, D. Y.; Furlong, L. I.; Biancotti, J. C.; Baker, H. ; et al.; Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa; Elsevier Inc; Fertility And Sterility; 93; 7; 1-5-2010; 2456-2459
0015-0282
1556-5653
Autor
Veaute, Carolina Melania Isabel
Liu, D. Y.
Furlong, L. I.
Biancotti, J. C.
Baker, H.
Vazquez, Monica Hebe
Resumen
The anti-acrosin monoclonal antibody AcrC5F10 inhibited proacrosin activation, proacrosin-human zona pellucida glycoprotein A (ZPA) binding, and the zona pellucida (ZP)-induced acrosome reaction of the ZP-bound spermatozoa but had no significant effect on sperm-ZP binding. These results suggest that proacrosin-acrosin may play an important role in the ZP-induced acrosome reaction of spermatozoa after primary binding to the ZP.