info:eu-repo/semantics/article
The genomes of four tapeworm species reveal adaptations to Parasitism
Fecha
2013-03Registro en:
Tsai, Isheng J.; Zarowiecki, Magdalena; Holroyd, Nancy; Garciarrubio, Alejandro; Sanchez Flores, Alejandro; et al.; The genomes of four tapeworm species reveal adaptations to Parasitism; Nature Publishing Group; Nature; 496; 7443; 3-2013; 57-63
0028-0836
1476-4687
Autor
Tsai, Isheng J.
Zarowiecki, Magdalena
Holroyd, Nancy
Garciarrubio, Alejandro
Sanchez Flores, Alejandro
Camicia, Federico
Cucher, Marcela Alejandra
Kamenetzky, Laura
Macchiaroli, Natalia
Rosenzvit, Mara Cecilia
Liu, Kan
Luo, Xuenong
Luo, Yingfeng
Nichol, Sarah
Paps, Jordi
Parkinson, John
Pouchkina Stantcheva, Natasha
Riddiford, Nick
Salinas, Gustavo
Wasmuth, James D.
Zamanian, Mostafa
Zheng, Yadong
The Taenia Solium Genome Consortium
Cai, Xuepeng
Soberón, Xavier
Olson, Peter D.
Laclette, Juan P.
Brehm, Klaus
Berriman, Matthew
Resumen
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115- to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control.