info:eu-repo/semantics/article
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
Fecha
2014-08Registro en:
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10
0006-4971
1528-0020
CONICET Digital
CONICET
Autor
Noris, Patrizia
Biino, Ginevra
Pecci, Alessandro
Civaschi, Elisa
Savoia, Anna
Seri, Marco
Melazzini, Federica
Loffreddo, Giuseppe
Russo, Giovana
Bozzi, Valeria
Notarangelo, Lucia Dora
Gresele, Paolo
Heller, Paula Graciela
Pujol Moix, Nuria
Kunishima, Shinji
Cattaneo, Marco
Bussel, James
de Candia, Erica
Cagioni, Claudia
Ramenghi, Ugo
Barozzi, Serena
Fabris, Fabrizio
Balduini, Carlo L.
Resumen
Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.