Artículos de revistas
Arrhythmogenic effect of androgens on the rat heart
Fecha
2017-01Registro en:
Argenziano, Mariana Alejandra; Tiscornia, Gisela Carla; Moretta, Rosalia Ester; Casal, Leonardo; Potilinski, María Constanza; et al.; Arrhythmogenic effect of androgens on the rat heart; Springer Tokyo; Journal Of Physiological Sciences; 67; 1; 1-2017; 217-225
1880-6546
CONICET Digital
CONICET
Autor
Argenziano, Mariana Alejandra
Tiscornia, Gisela Carla
Moretta, Rosalia Ester
Casal, Leonardo
Potilinski, María Constanza
Amorena, Carlos Ernesto
Garcia Gras, Eduardo Andres
Resumen
In most species androgens shorten the cardiac action potential and reduce the risk of afterdepolarizations. Despite the central role of the rat model in physiological studies, the effects of androgens on the rat heart are still inconclusive. We therefore performed electrophysiological studies on the perfused rat right ventricular free wall. We found a correlation between androgenic activity and a propensity to generate ventricular ectopic action potentials. We also found that the testosterone treatment increased action potential duration at 90 % of repolarization (APD90), while androgenic inhibition increased the time to peak and decreased APD90. We observed that the voltage-gated potassium channel Kv4.3 and the bi-directional membrane ion transporter NCX in the rat myocardium were regulated by androgenic hormones. One possible explanation for these findings is that due to the expression of specific ion channels in the rat myocardium, the action potential response to its hormonal background is different from those described in other experimental models. Our results indicate that androgenic control of NCX expression plays a key role in determining arrhythmogenicity in the rat heart.