Artículos de revistas
Animal models in diabetes and pregnancy
Jawerbaum, Alicia Sandra; White, Verónica; Animal models in diabetes and pregnancy; Oxford University Press; Endocrine Reviews.; 31; 5; 10-2010; 680-701
Jawerbaum, Alicia Sandra
The worldwide increase in the incidence of diabetes, the increase in type 2 diabetes in women at reproductive ages, and the cross-generation of the intrauterine programming of type 2 diabetes are the bases for the growing interest in the use of experimental diabetic models in order to gain insight into the mechanisms of induction of developmental alterations in maternal diabetes. In this scenario, experimental models that present the most common features of diabetes in pregnancy are highly required. Several important aspects of human diabetic pregnancies such as the increased rates of spontaneous abortions, malformations, fetoplacental impairments, and offspring diseases in later life can be approached by using the appropriate animal models. The purpose of this review is to give a practical and critical guide into the most frequently used experimental models in diabetes and pregnancy, discuss their advantages and limitations, and describe the aspects of diabetes and pregnancy for which these models are thought to be adequate. This review provides a comprehensive view and an extensive analysis of the different models and phenotypes addressed in diabetic animals throughout pregnancy. The review includes an analysis of the surgical, chemical-induced, and genetic experimental models of diabetes and an evaluation of their use to analyze early pregnancy defects, induction of congenital malformations, placental and fetal alterations, and the intrauterine programming of metabolic diseases in the offspring’s later life.
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Relación entre el apoyo social y las complicaciones agudas de la diabetes tipo 2: un estudio de corte transversal Teherán Valderrama, Aníbal Alfonso; Mejía Guatibonza, María Camila; Álvarez Meza, Luz; Muñoz Ramírez, Yenny José; Barrera Céspedes, María; Cadavid González, Vanessa (Universidad del Rosario, 2017)Objective: To evaluate the relationship between social support and the frequency of patients with acute complications of type 2diabetes. Materials and methods: A cross-sectional study was carried out on type 2 diabetic ...
Negrato, Carlos Antonio; Montenegro Junior, Renan Magalhães; Von Kostrisch, Lilia Maria; Guedes, Maria Fatima; Mattar, Rosiane; Gomes, Marilia de Brito (Sociedade Brasileira de Endocrinologia e Metabologia, 2012-10-01)Pregnancy affects both maternal and fetal metabolism, and even in non-diabetic women, it exerts a diabetogenic effect. Among pregnant women, 2% to 14% develop gestational diabetes. Pregnancy can also occur in women with ...
Negrato, Carlos Antonio; Montenegro Junior, Renan Magalhães; Von Kostrisch, Lilia Maria; Guedes, Maria Fatima; Mattar, Rosiane; Gomes, Marilia B. (Sociedade Brasileira de Endocrinologia e Metabologia, 2012)Pregnancy affects both maternal and fetal metabolism, and even in non-diabetic women, it exerts a diabetogenic effect. Among pregnant women, 2% to 14% develop gestational diabetes. Pregnancy can also occur in women with ...