Artículos de revistas
Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells
Fecha
2017-09Registro en:
Noto Llana, Mariangeles; Sarnacki, Sebastian Hernan; Morales, Andrea Lorena; Aya Castañeda, Maria del Rosario; Giacomodonato, Mónica Nancy; et al.; Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells; Frontiers; Frontiers in Cellular and Infection Microbiology; 7; 9-2017
2235-2988
CONICET Digital
CONICET
Autor
Noto Llana, Mariangeles
Sarnacki, Sebastian Hernan
Morales, Andrea Lorena
Aya Castañeda, Maria del Rosario
Giacomodonato, Mónica Nancy
Blanco, Guillermo Armando C.
Cerquetti, Maria Cristina
Resumen
Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA. Although the pathogenesis remains unclear, it is known that IL-17 plays a pivotal role in the development of ReA. IL-17-producers cells are mainly Th17, iNKT, and γδT lymphocytes. It is known that iNKT cells regulate the development of Th17 lineage. Whether iNKT cells also regulate γδT lymphocytes differentiation is unknown. We found that iNKT cells play a protective role in ReA. BALB/c Jα18−/− mice suffered a severe Salmonella enterocolitis, a 3.5-fold increase in IL-17 expression and aggravated inflammation of the synovial membrane. On the other hand, activation of iNKT cells with α-GalCer abrogated IL-17 response to Salmonella enterocolitis and prevented intestinal and joint tissue damage. Moreover, the anti-inflammatory effect of α-GalCer was related to a drop in the proportion of IL-17-producing γδT lymphocytes (IL17-γδTcells) rather than to a decrease in Th17 cells. In summary, we here show that iNKT cells play a protective role against Salmonella-enterocolitis and Salmonella-induced ReA by downregulating IL17-γδTcells.