Artículos de revistas
Poly (polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents
Fecha
2016-10Registro en:
Navarro, Lucila; Mogosanu, Diana; de Jong, Thijs; Bakker, Astrid; Schaubroeck, David; et al.; Poly (polyol sebacate) Elastomers as Coatings for Metallic Coronary Stents; Wiley-vch, Inc; Macromolecular Bioscience; 16; 11; 10-2016; 1678-1692
1616-5195
CONICET Digital
CONICET
Autor
Navarro, Lucila
Mogosanu, Diana
de Jong, Thijs
Bakker, Astrid
Schaubroeck, David
Luna, Julio Alberto
Rintoul, Ignacio
Vanfleteren, Jan
Dubruel, Peter
Resumen
Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and restenosis, require new materials to be studied. For this purpose, novel poly(polyol sebacate)-derived polymers are investigated as coatings for metallic stents. All pre-polymers reveal a low molecular weight between 3000 and 18 000 g mol−1. The cured polymers range from flexible to more rigid, with E-modulus between 0.6 and 3.8 MPa. Their advantages include straightforward synthesis, biodegradability, easy processing through different scaffolding techniques, and easy transfer to industrial production. Furthermore, electrospraying and dip-coating procedures are used as proof-of-concept to create coatings on metallic stents. Biocompatibility tests using adipose stem cells lead to promising results for the use of these materials as coatings for metallic coronary stents.