Artículos de revistas
Incorporation of Magnetic Nanoparticles in Poly(Methyl Methacrylate) Nanocapsules
Fecha
2017-03Registro en:
Ronco, Ludmila Irene; Feuser, Paulo Emilio; da Cas Viegas, Alexandre; Minari, Roque Javier; Gugliotta, Luis Marcelino; et al.; Incorporation of Magnetic Nanoparticles in Poly(Methyl Methacrylate) Nanocapsules; Wiley VCH Verlag; Macromolecular Chemistry And Physics; 219; 6; 3-2017; 1700424_1-1700424_7
1022-1352
CONICET Digital
CONICET
Autor
Ronco, Ludmila Irene
Feuser, Paulo Emilio
da Cas Viegas, Alexandre
Minari, Roque Javier
Gugliotta, Luis Marcelino
Sayer, Claudia
Araújo, Pedro H. H.
Resumen
Magnetic nanoparticles (MNPs) encapsulated in polymeric systems are promising materials for hyperthermia treatments and targeting drug delivery in cancer therapy. To improve the encapsulation efficiency of therapeutic drugs, high amounts of fatty acids can be incorporated into the polymer matrix. The effect of the monounsaturated fatty acid oleic acid (OA)/Crodamol (triacylglycerol of saturated fatty acids) ratio in the incorporation of MNPs in poly(methyl methacrylate) (PMMA) nanocapsules by miniemulsion polymerization is investigated. The OA/Crodamol ratio affects polymerization kinetics, polymer microstructure, and nanocapsules morphology. Furthermore, MNPs are efficiently encapsulated in PMMA nanocapsules with high Crodamol content while preserving their super-paramagnetic behavior with considerable magnetization saturation values.