Artículos de revistas
Vaccines against bovine babesiosis: where we are now and possible roads ahead
Fecha
2014-07Registro en:
Jacobsen, Monica Ofelia; Suarez, Carlos E.; Rodriguez, Anabel Elisa; Flores, Daniela Agustina; Schnittger, Leonhard; Vaccines against bovine babesiosis: where we are now and possible roads ahead; Cambridge University Press; Parasitology; 141; 12; 7-2014; 1563-1592
0031-1820
CONICET Digital
CONICET
Autor
Jacobsen, Monica Ofelia
Suarez, Carlos E.
Rodriguez, Anabel Elisa
Flores, Daniela Agustina
Schnittger, Leonhard
Resumen
Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems.