info:eu-repo/semantics/article
Striped, bioactive Ce-TiO2 material with peroxynitrite-scavenging activity
Fecha
2014-02Registro en:
Gravina, Noel; Ruso, Juan M.; Laiuppa, Juan Andrés; Santillán, Graciela Edith; Marco Brown, José Luis; et al.; Striped, bioactive Ce-TiO2 material with peroxynitrite-scavenging activity; Royal Society of Chemistry; Journal of Materials Chemistry B; 7; 2-2014
2050-750X
CONICET Digital
CONICET
Autor
Gravina, Noel
Ruso, Juan M.
Laiuppa, Juan Andrés
Santillán, Graciela Edith
Marco Brown, José Luis
D'elía, Noelia Laura
Messina, Paula Verónica
Resumen
Controlling aligned fiber micro-architectures to simulate the extracellular matrix for inducing important biological functions is a key challenge with regard to successful tissue regeneration. Here we present a bottom-up microemulsion-mediated strategy to obtain highly bioactive and biocompatible, striped Ce–TiO2 nano-crystalline superstructures with ONOO− scavenging activity. The employment of a bulkier organic ceria precursor in the material synthesis has several concurrent effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nanoparticles causing the final lined morphology, (II) stabilizing the anatase active phase in a fine dispersed state and improving its resistance to the thermal anatase–rutile conversion, (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of sphere-like globules of 3–5 μm in diameter essential for bone-bonding, and finally (IV) accelerating the ONOO− degradation into less harmful species NO2− and O2.