Artículos de revistas
Volatiles from Subtropical Convolvulaceae That Interfere with Bacterial Cell-to-Cell Communication as Potential Antipathogenic Drugs
Fecha
2016-05Registro en:
Luciardi, María Constanza; Pérez Hernández, María Victoria; Muruaga, Nora; Bardon, Alicia del Valle; Arena, Mario Eduardo; et al.; Volatiles from Subtropical Convolvulaceae That Interfere with Bacterial Cell-to-Cell Communication as Potential Antipathogenic Drugs; Hindawi Publishing Corporation; Evidence-Based Complementary and Alternative Medicine; 2016; 5-2016; 1-8
1741-427X
1741-4288
CONICET Digital
CONICET
Autor
Luciardi, María Constanza
Pérez Hernández, María Victoria
Muruaga, Nora
Bardon, Alicia del Valle
Arena, Mario Eduardo
Cartagena, Elena
Resumen
Increasing chronic bacterial infections create an urgent need for new antimicrobial agents or strategies for their control. Targetingvirulence is one of the alternative approaches to find new medicines to treat persistent infections due to bacteria with biofilmphenotypewhich are more resistant to antibiotics than their planktonic counterparts having an extreme capacity for evading the host defences. A bioguided study of sixteen extracts from flowers and leaves of four subtropical Convolvulaceae species provided evidence of the occurrence of antipathogenic natural products active against Gram positive and negative bacteria.Particularly, volatile metabolites from Merremia dissecta creeper, a food and medicinal plant, were able to interfere with the Pseudomonas aeruginosa quorum sensing system by a strong decrease of N-acyl homoserine lactone (AHL) biosynthesis (63?75%), which attenuated the virulence factor expression like biofilm (55%) and elastase activity (up to 27%), key factors thatenable the colonization and dissemination of the infection in the host. Control of the P. aeruginosa biofilm and the QS process by phytochemicals, such as (+) spathulenol, isolated from a bioactive extract of M. dissecta leaves would be a good strategy for the development of new and effective antipathogenic drugs.