Artículos de revistas
Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake
Fecha
2015-08Registro en:
Dalmasso, Carolina; Antunes Rodrigues, José; Vivas, Laura Marta; De Luca, Laurival A.; Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 151; 8-2015; 494-501
0031-9384
CONICET Digital
CONICET
Autor
Dalmasso, Carolina
Antunes Rodrigues, José
Vivas, Laura Marta
De Luca, Laurival A.
Resumen
Water deprivation (WD) followed by water intake to satiety, produces satiation of thirst and partial rehydration (PR). Thus, WD-PR is a natural method to differentiate thirst from sodium appetite. WD-PR also produces Fos immunoreactivity (Fos-ir) in interconnected areas of a brain circuit postulated to subserve sodium appetite. In the present work, we evaluated the effect of sodium intake on Fos-ir produced by WD-PR in brain areas operationally defined according to the literature as either facilitatory or inhibitory to sodium intake. Isotonic NaCl was available for ingestion in a sodium appetite test performed immediately after a single episode of WD-PR. Sodium intake decreased Fos-ir in facilitatory areas such as the lamina terminalis (particularly subfornical organ and median preoptic nucleus), central amygdala and hypothalamic parvocellular paraventricular nucleus in the forebrain. Sodium intake also decreased Fos-ir in inhibitory areas such as the area postrema, lateral parabrachial nucleus and nucleus of the solitary tract in the hindbrain. In contrast, sodium intake further increased Fos-ir that was activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain. WD-PR increased Fos-ir in the core and shell of the nucleus accumbens. Sodium intake reduced Fos-ir in both parts of the accumbens. In summary, sodium intake following WD-PR reduced Fos-ir in most facilitatory and inhibitory areas, but increased Fos-ir in another inhibitory area. It also reduced Fos-ir in a reward area (accumbens). The results suggest a functional link between sodium intake and the activity of the hindbrain-forebrain circuitry subserving reward and sodium appetite in response to water deprivation.