info:eu-repo/semantics/article
Chemistry and Biological Activity of Coumarins at Molecular Level
Fecha
2014-08Registro en:
Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094
1934-578X
Autor
Garro, Hugo Alejandro
García, Celina
Martin, Víctor S.
Pungitore, Carlos Rodolfo
Tonn, Carlos Eugenio
Resumen
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.