Chemistry and Biological Activity of Coumarins at Molecular Level

Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio

Artículos de revistas

Date

2014-08

Registration in:

Garro, Hugo Alejandro; García, Celina; Martin, Víctor S.; Pungitore, Carlos Rodolfo; Tonn, Carlos Eugenio; Chemistry and Biological Activity of Coumarins at Molecular Level; Natural Products; Natural Product Communications; 9; 8; 8-2014; 1091-1094

1934-578X

http://hdl.handle.net/11336/5886

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1882705

Author

Garro, Hugo Alejandro

García, Celina

Martin, Víctor S.

Pungitore, Carlos Rodolfo

Tonn, Carlos Eugenio

Institutions

Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)

Abstract

Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have showed interesting activity against Taq DNA polymerase with IC50 values of 115.74 μM and 82.24 μM, respectively. Also, the compounds 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) have exhibited inhibitory activity against MMLV-RT with IC50 values of 23.46 μM and 18.35 μM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also in the development of antitumor drugs.

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