info:eu-repo/semantics/article
Glycobiology of cell death: when glycans and lectins govern cell fate
Date
2013-07Registration in:
Lichtenstein, Rachel; Rabinovich, Gabriel Adrian; Glycobiology of cell death: when glycans and lectins govern cell fate; Nature Publishing Group; Cell Death And Differentiation; 20; 8; 7-2013; 976-986
1350-9047
1476-5403
Author
Lichtenstein, Rachel
Rabinovich, Gabriel Adrian
Abstract
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.