Artículos de revistas
Antifungal Terpenoids from Hyalis argentea var. latisquama
Fecha
2014-07Registro en:
Sánchez, Marianela; Palermo, Jorge Alejandro; Zacchino, Susana Alicia Stella; Svetaz, Laura Andrea; Butassi, Estefanía; Fernandez, Lucia Raquel; et al.; Antifungal Terpenoids from Hyalis argentea var. latisquama
; American Chemical Society; Journal of Natural Products; 77; 7; 7-2014; 1579-1585
0163-3864
CONICET Digital
CONICET
Autor
Fernandez, Lucia Raquel
Butassi, Estefanía
Svetaz, Laura Andrea
Zacchino, Susana Alicia Stella
Palermo, Jorge Alejandro
Sánchez, Marianela
Resumen
A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity.