info:eu-repo/semantics/article
Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
Fecha
2014-12Registro en:
Goszczynski, Daniel Estanislao; Papaleo Mazzucco, Juliana; Ripoli, María Verónica; Villareal, Edgardo Leopoldo; Rogberg Muñoz, Andres; et al.; Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat; Elsevier Science; Meta Gene; 2; 12-2014; 746-760
2214-5400
CONICET Digital
CONICET
Autor
Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villareal, Edgardo Leopoldo
Rogberg Muñoz, Andres
Mezzadra, Carlos Alberto
Melucci, Lilia Magdalena
Giovambattista, Guillermo
Resumen
LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a variety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unrelated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle population. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health.