Artículos de revistas
Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia
Fecha
2014-08Registro en:
European Hematology Association Scientific Working Group on Thrombocytopenias and Platelet Function Disorders; Balduini, Carlo L.; Savoia, Anna; Marconi, Caterina; Lecompte, Thomas; Randi, Maria Luigia; et al.; Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia; Ferrata Storti Foundation; Haematologica; 99; 8; 8-2014; 1387-1394
0390-6078
1592-8721
CONICET Digital
CONICET
Autor
Noris, Patrizia
Schlegel, Nicole
Klersy, Catherine
Heller, Paula Graciela
Civaschi, Elisa
Pujol Moix, Nuria
Fabris, Fabrizio
Favier, Remi
Gresele, Paolo
Latger Cannard, Véronique
Cuker, Adam
Nurden, Paquita
Greinacher, Andreas
Cattaneo, Marco
De Candia, Erica
Pecci, Alessandro
Hurtaud Roux, Marie Françoise
Glembotsky, Ana Claudia
Muñiz Diaz, Eduardo
Randi, Maria Luigia
Trillot, Nathalie
Bury, Loredana
Lecompte, Thomas
Marconi, Caterina
Savoia, Anna
Balduini, Carlo L.
European Hematology Association Scientific Working Group on Thrombocytopenias and Platelet Function Disorders
Resumen
Pregnancy in women with inherited thrombocytopenias is a major matter of concern as both the mothers and the newborns are potentially at risk of bleeding. However, medical management of this condition cannot be based on evidence because of the lack of consistent information in the literature. To advance knowledge on this matter, we performed a multicentric, retrospective study evaluating 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. Neither the degree of thrombocytopenia nor the severity of bleeding tendency worsened during pregnancy and the course of pregnancy did not differ from that of healthy subjects in terms of miscarriages, fetal bleeding and pre-term births. The degree of thrombocytopenia in the babies was similar to that in the mother. Only 7 of 156 affected newborns had delivery-related bleeding, but 2 of them died of cerebral hemorrhage. The frequency of delivery-related maternal bleeding ranged from 6.8% to 14.2% depending on the definition of abnormal blood loss, suggesting that the risk of abnormal blood loss was increased with respect to the general population. However, no mother died or had to undergo hysterectomy to arrest bleeding. The search for parameters predicting delivery-related bleeding in the mother suggested that hemorrhages requiring blood transfusion were more frequent in women with history of severe bleedings before pregnancy and with platelet count at delivery below 50 × 10(9)/L.