Artículos de revistas
Enantiocomplementary Access to Carba-Analogs of C-Nucleoside Derivatives by Recombinant Baeyer-Villiger Monooxygenases
Fecha
2013-03Registro en:
Bianchi, Dario Alejandro; Moran Ramallal, Roberto; Iqbal, Naseem; Rudroff, Florian; Mihovilovic, Marko D.; Enantiocomplementary Access to Carba-Analogs of C-Nucleoside Derivatives by Recombinant Baeyer-Villiger Monooxygenases; Elsevier; Bioorganic & Medicinal Chemistry Letters; 23; 9; 3-2013; 2718-2720
0960-894X
Autor
Bianchi, Dario Alejandro
Moran Ramallal, Roberto
Iqbal, Naseem
Rudroff, Florian
Mihovilovic, Marko D.
Resumen
A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer–Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material.