info:eu-repo/semantics/article
Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems
Fecha
2016-05Registro en:
Cuggino, Julio César; Molina, Maria; Wedepohl, Stefanie; Alvarez Igarzabal, Cecilia Ines; Calderon, Marcelo; et al.; Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems; Elsevier; European Polymer Journal; 78; 5-2016; 14-24
0014-3057
1873-1945
Autor
Cuggino, Julio César
Molina, Maria
Wedepohl, Stefanie
Alvarez Igarzabal, Cecilia Ines
Calderon, Marcelo
Gugliotta, Luis
Resumen
Various specially designed poly(N-isopropylacrylamide-co-acrylic acid) (NIPA-co-AAc) nanogels (NGs) with different NIPA/AAc molar composition were synthesized by precipitation/dispersion polymerization and evaluated as carriers for drug delivery systems (DDSs) of doxorubicin hydrochloride (DOXO·HCl) for cancer therapies. The NGs presented excellent dispersability in physiological environments (pH 7.4 and 5 at 37 °C), as shown by dynamic light scattering (DLS). Moreover, the NGs exhibited high drug loading capacity and efficiency due to the ionic interaction of the cationic drug with the anionic NGs. NG-DOXO·HCl formulation presented excellent dispersability in water and minimal leakage of the cargo at plasma simulated medium (pH 7.4 and 0.14 M NaCl) at 37 °C and a triggered release at lysosomal simulated medium (pH 5 and 0.14 M NaCl). This release behavior together with their size and the low cytotoxicity determined by the MTT assay converts these NGs in great candidates for their application as carriers in cancer therapies based on the enhanced permeability and retention effect (EPR) with drug pH-triggered release after endocytosis in tumor cells.