Artículos de revistas
Standardization of molecular monitoring for chronic myeloid leukemia in Latin America using locally produced secondary cellular calibrators
Fecha
2016-12Registro en:
Ruiz, María Sol; Medina, M.; Tapia, I.; Mordoh, Jose; Cross, N. C. P.; et al.; Standardization of molecular monitoring for chronic myeloid leukemia in Latin America using locally produced secondary cellular calibrators; Nature Publishing Group; Leukemia; 30; 11; 12-2016; 2258-2260
0887-6924
CONICET Digital
CONICET
Autor
Ruiz, María Sol
Medina, M.
Tapia, I.
Mordoh, Jose
Cross, N. C. P.
Larripa, Irene Beatriz
Bianchini, Michele
Resumen
Residual disease in chronic myeloid leukemia (CML) patients undergoing therapy with tyrosine kinase inhibitors (TKIs) is measured by assessing the quantity of transcripts of the BCR-ABL1 fusion gene in peripheral white blood cells. This analysis is based on reverse-transcription quantitative PCR (RT–qPCR) technology; however, the wide array of methods used worldwide has led to large variation in quantitative BCR-ABL1 measurements, which hamper inter-laboratory comparative studies