Artículos de revistas
A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories
Fecha
2017-08Registro en:
Ferrer Monti, Roque Ignacio; Alfei Palloni, Joaquin Matías; Mugnaini, Matías; Bueno, Adrián Marcelo; Beckers, Tom; et al.; A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories; Cold Spring Harbor Lab Press; Learning & Memory (Cold Spring Harbor, N.Y.); 24; 8; 8-2017; 369-374
1072-0502
1549-5485
CONICET Digital
CONICET
Autor
Ferrer Monti, Roque Ignacio
Alfei Palloni, Joaquin Matías
Mugnaini, Matías
Bueno, Adrián Marcelo
Beckers, Tom
Urcelay, Gonzalo Pablo
Molina, Víctor Alejandro
Resumen
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery. We found both treatments to be equally effective in both experiments. This study suggests that parameters leading to memory destabilization during reactivation are critical to observe long-lasting effects of MDZ or reactivation plus extinction.