Artículos de revistas
Neurogenetics in Argentina: diagnostic yield in a personalized research based clinic.
Fecha
2015-01Registro en:
Rodríguez Quiroga, Sergio Alejandro; Córdoba, Marta; González Morón, Dolores; Medina, Nancy; Vega, Patricia; et al.; Neurogenetics in Argentina: diagnostic yield in a personalized research based clinic.; Cambridge University Press; Genetical Research; 97; 1-2015; 1-10; e10
0016-6723
Autor
Rodríguez Quiroga, Sergio Alejandro
Córdoba, Marta
González Morón, Dolores
Medina, Nancy
Vega, Patricia
Vazquez Dusefante, Cecilia
Arakaki, Tomoko
Garreto, Nélida Susana
Kauffman, Marcelo Andres
Resumen
As a whole neurogenetic diseases are a common group of neurological disorders. However, the recognition and molecular diagnosis of these disorders is not always straightforward. Besides, there is a paucity of information regarding the diagnostic yield that specialized neurogenetic clinics could obtain. We performed a prospective, observational, analytical study of the patients seen in a neurogenetic clinic at a tertiary medical centre to assess the diagnostic yield of a comprehensive diagnostic evaluation that included a personalized clinical assessment along with traditional and next-generation sequencing diagnostic tests. We included a cohort of 387 patients from May 2008 to June 2014. For sub-group analysis we selected a sample of patients whose main complaint was the presence of progressive ataxia, to whom we applied a systematic molecular diagnostic algorithm. Overall, a diagnostic mutation was identified in 27·4% of our cohort. However, if we only considered those patients where a molecular test could be performed, the success rate rises to 45%. We obtained diagnostic yields of 23·5 and 57·5% in the global group of ataxic patients and in the subset of ataxic patients with a positive family history, respectively. Thus, about a third of patients evaluated in a neurogenetic clinic could be successfully diagnosed.