Argentina
| info:eu-repo/semantics/article
Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones
Fecha
2016-10Registro en:
Faccone, Diego Francisco; Lopez Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; et al.; Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones; Elsevier Science; Infection, Genetics and Evolution; 44; 10-2016; 507-509
1567-1348
CONICET Digital
CONICET
Autor
Faccone, Diego Francisco
Lopez Ruitti, Paula
Vazquez, Miryam
Guerriero, Leonor
Lucero, Celeste
Gagetti, Paula Silvana
Ceriana, Paola
Corso, Alejandra
Resumen
We report an H. parainfluenzae clinical isolate resistant to cefotaxime and with decreased susceptibility to ciprofloxacinrecovered from a patient with cystic fibrosis. The isolate had elevated MICs of ampicillin (256 mg/L), amoxicillin-clavulanate(8 mg/L), cefuroxime (8 mg/L) and cefotaxime (4 mg/L), and showed a β-lactamase-producing amoxicillin-clavulanicacid-resistant (BLPACR) phenotype. A blaTEM-1 plus five amino acid substitutions in the PBP3 were found:Ser385Thr, Val511Ala, Ile519Val, Asn526Lys and Asp551Leu. MIC of ciprofloxacin was 0.5 mg/L, and substitutions ingyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.