info:eu-repo/semantics/article
HIV mother-to-child transmission: A complex genetic puzzle tacked by Brazil and Argentina research teams
Fecha
2013-03Registro en:
Da Silva, R. Celerino; Bedin, E.; Mangano, Andrea María Mercedes; Aulicino, Paula; Pontillo, A.; et al.; HIV mother-to-child transmission: A complex genetic puzzle tacked by Brazil and Argentina research teams; Elsevier; Infection, Genetics and Evolution; 19; 3-2013; 1-12
1567-1348
CONICET Digital
CONICET
Autor
Da Silva, R. Celerino
Bedin, E.
Mangano, Andrea María Mercedes
Aulicino, Paula
Pontillo, A.
Brandão, L.
Guimarães, R.
Arraes, L. C.
Sen, Luisa
Crovella, Sergio
Resumen
Human immunodeficiency virus (HIV) mother-to-child transmission is a complex event, depending upon environmental factors and is affected by host genetic factors from mother and child, as well as viral genetic elements. The integration of multiple parameters (CD4 cell count, virus load, HIV subtype, and host genetic markers) could account for the susceptibility to HIV infection, a multifactorial trait. The goal of this manuscript is to analyze the immunogenetic factors associated to HIV mother-to-child transmission, trying to unravel the genetic puzzle of HIV mother-to-child transmission and considering the experience in this topic of two research groups from Brazil and Argentina.