Artículos de revistas
Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer
Fecha
2015-10Registro en:
Brito, Gilmar A.; Sarotti, Ariel Marcelo; Wipf, Peter; Pilli, Ronaldo A.; Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer; Elsevier; Tetrahedron Letters; 56; 48; 10-2015; 6664-6668
0040-4039
Autor
Brito, Gilmar A.
Sarotti, Ariel Marcelo
Wipf, Peter
Pilli, Ronaldo A.
Resumen
A concise formal synthesis of stemoamide ( 1) and its 9a-epimer 14in 5 steps is described featuring a cas-cade cyclization triggered by imine formation. A good selectivity for either epimer is readily accom-plished by variation of the ester ( 9bor 9a, respectively) and the reaction conditions.