info:eu-repo/semantics/article
Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model
Fecha
2017-02Registro en:
Herrera, María Inés; Otero-Losada, Matilde Estela; Udovin, Lucas Daniel; Kusnier, Carlos Federico; Kolliker Frers, Rodolfo Alberto; et al.; Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model; Hindawi Publishing Corporation; Neural Plasticity; 2017; 2-2017; 1-8
2090-5904
CONICET Digital
CONICET
Autor
Herrera, María Inés
Otero-Losada, Matilde Estela
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Kolliker Frers, Rodolfo Alberto
de Souza, Wanderley
Capani, Francisco
Resumen
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.