Argentina
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Binding of Sulfamethazine to β-cyclodextrin and Methyl-β-cyclodextrin
Fecha
2013-04Registro en:
Zoppi, Ariana; Delrivo, Alicia; Aiassa, Virginia; Longhi, Marcela Raquel; Binding of Sulfamethazine to β-cyclodextrin and Methyl-β-cyclodextrin; Springer; AAPS Pharmscitech; 14; 2; 4-2013; 727-735
1530-9932
CONICET Digital
CONICET
Autor
Zoppi, Ariana
Delrivo, Alicia
Aiassa, Virginia
Longhi, Marcela Raquel
Resumen
β-cyclodextrin (βCD) and methyl-β-cyclodextrin (MβCD) complexes with sulfamethazine (SMT) were prepared and characterized by different experimental techniques, and the effects of βCD and MβCD on drug solubility were assessed via phase-solubility analysis. The phase-solubility diagram for the drug showed an increase in water solubility, with the following affinity constants calculated: 40.4 ± 0.4 (pH 2.0) and 29.4 ± 0.4 (pH 8.0) M−1 with βCD and 56 ± 1 (water), 39 ± 3 (pH 2.0) and 39 ± 5 (pH 8.0) M−1 with MβCD. According to 1H NMR and 2D NMR spectroscopy, the complexation mode involved the aromatic ring of SMT included in the MβCD cavity. The complexes obtained in solid state by freeze drying were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and thermal analysis. The amorphous complexes obtained in this study may be useful in the preparation of pharmaceutical dosage forms of SMT.